Understanding health economics and outcomes research (HEOR) from a non-health economist lens!

Remember the dilemma of Alan Turing from the movie The Imitation Game where to optimize for a war winning strategy he happened to decide on the fate of American soldiers?
Sometimes people have to play God as we have to accept the harsh truth of life that “everybody cannot be saved”, unless human species advances to the level of octopus-like-aliens from the movie Arrival!

Consider a similar scenario where the war ground is replaced by a hypothetical island hit by a pandemic and soldiers dying are replaced by patients affected by the pandemic and Guliver is the fortunate (or the unfortunate) health economist who has to decide on allocation of limited healthcare budget.

Also, let’s assume that historically the government has been spending all of the budget on curing insomnia which happened to be the only disease among people there. The mortality rate accrued to insomnia under no medication was estimated to be 2% which under medication reduces to 0% . For the pandemic the mortality rate is 5%. The government is ready to fund research for the treatment though there is no certainty of success even if they pool all the funds into research for pandemic cure.

So, there is an economics to health as governments have a limited budget to spend on healthcare services and it’s crucial to optimize this budget over various healthcare facilities and technologies.

Luckily, the island has good data practices which can help Guliver (the health economist) to design a mathematical problem with an objective function and budget constraints.

There are core assumptions in this simplified version which can be dropped going further. A few of them as follows:

Different individuals can have different chances of survival
All lives are equally important for the government.
Quality of life after treatment is assumed to be same for everyone
Individuals with the same level of health are assumed to be equally happy, hence maximising aggregate social welfare measured in terms of aggregate individual utility will give the same results.

So the problem narrows down to estimating survival probability for individuals which can depend on various factors such as –

Patient-specific factors- age, gender, medical history, sanitation, heredity, social exposure
Awareness-specific factors – social distancing measures, expenditure on awareness
Political and social factors – poverty, unemployment rates
Disease and treatment specific factors – Nature of the disease (or severity levels), available treatments, adverse effects
Other factors – qualification/ capability of researchers in the country, time given for research, ability to produce new research

Once the functional relationship between the individual survival probabilities and various affecting factors is determined (which can be done using traditional or advanced mathematical and statistical approaches), Guliver can weigh up the benefits and costs of healthcare services to decide whether they are good value for money (or within the threshold of budget) in the pandemic time. These analyses will help in decision-making, which allows the government to provide the best healthcare to people in the island.

This is a major component of a Health Economics and Outcomes Research (HEOR) research or job. The market for HEOR was 0.7 billion in the year 2019, and is predicted to continue to grow in the coming decade. The market size will rise even during or after the current COVID-19 pandemic time, as it is currently most essential than ever to conduct value-based analysis and evidence based research.

There will be a growing need for HEOR in emerging economies as the health technology assessment (HTA) systems sprout or develop in these countries. Regarding the future of HEOR- The emerging use of machine learning, real world evidence data, digital healthcare, and precision medicine is initiating a new wave of research into HEOR.

Let’s prioritize evidence-based research for safe, affordable and efficient healthcare delivery!

Author – Kunal Hriday

24 Responses

      1. Great insight on HEOR.
        Thank you for sharing such an article. I’m gonna go back and watch the imitation game movie, so I can relate well.

  1. Heya im for the first time here. I found this board and I find It really useful & it helped me out much. I hope to give something back and aid others like you helped me.

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Judit Banhazi

Specialty
Value and Access

Role
Vice President

Degree
MD Medicine, JD Law

Judit Banhazi

MD Medicine, JD Law

Judit Banhazi, based in Basel, Switzerland, brings over 20 years of experience in HEOR, Market Access, and Health Policy.
She has led HEOR strategies in hematology and initiated EU HTA policy activities. Judit began her career as a physician and has worked at prime global pharma companies. Her academic prowess is excellent with a peculiar combination of an MD in Medicine and a JD in Law, she has been at forefront of health economics by being involved in HTA policy discussions with EFPIA and HTAi.
Known for her collaborative spirit and practical approach, Judit is passionate about learning and delivering quality work. Outside of work, she enjoys spending time with family and friends, travelling, and running.

Adam Ball

Specialty
Business Development Manager

 

Adam Ball

Business Manager

I am delighted to be part of the team here at ConnectHEOR. To tell you a bit about me, I have 10 years experience within Talent Acquisition within HEOR, RWE and Market Access. I have built a global network during this time and am excited to utilize this to help us grow as business. 

 

Outside of work I love sports, playing football and squash regularly, as well as going to the gym. I also enjoy watching sports mainly football and tennis. I have a new born daughter too so she is taking up a lot of my time and is a bundle of joy. I also play drums and like to think I have a broad taste in Music.

 

Eleni Tente

Specialty
Medical writing, Evidence planning

Role
Consultant, Medical writer

Degree
PhD – Molecular biology and genetics

Eleni Tente

PhD – Molecular biology and genetics

Eleni Tente is an experienced medical writer with proven ability to translate complex scientific information into clear, concise, and impactful content to diverse audiences. She has a strong background in integrated evidence planning, publications, internal communications and e-learning development, complemented by an understanding of various therapeutic areas.

Eleni holds a PhD in molecular biology and genetics from the University of Cambridge and an MSc in plant genetic manipulation from the University of Nottingham.

In her free time, Eleni enjoys diving into a good book, fishing along the coast, or planning her next thrilling scuba diving adventure to swim with sharks.

Syed Salleh

Specialty
HTA Modelling and Discrete-event Simulation

Role
Consultant, Modeling & Analytics

Degree
PhD – Health & Related Research

Syed Salleh

PhD. Health & Related Research

Syed Salleh brings extensive experience in HTA modeling, having successfully led the development of both de novo and adaptation models for HTA listings across multiple countries, including Malaysia, Philippines, and the UK. His work spans key therapeutic franchises such as oncology, cardiometabolic, and respiratory. Syed has also delivered critical insights to healthcare professionals through MYSPOR, ITTP, and IKN virtual CME events and numerous publications.

He holds a PhD in Health and Related Research from the School of Health and Related Research (ScHARR) at the University of Sheffield, UK, with a specialization in HTA and operational research, specifically in discrete-event simulation (DES) technique.

During his time in a leading pharmaceutical company, Syed played a key role in securing the listing of several key products in the Malaysia Ministry of Health Formulary and served as the primary contact for DES-related projects.

Besides work, Syed enjoys traveling, listening to music, and spending quality time with his family.

Thai-Son Tong

Specialty
Model Conceptualization and Data Analytics

Role
Senior Consultant

Degree
PhD – Health Economics

Thai-Son Tong

PhD. Health Economics

Thaison Tong has extensive work experience in health economics, decision modelling and big data analysis. He has a unique mix of experience in HEOR and RWE related research in academia and pharmaceutical industry. His expertise lies in health technology assessments (HTA), health economic modelling, simulation modelling, big data analytics and decision analysis. He has hands-on experience in a range of software and programming languages including R, R Shiny, R Markdown, Python, MS Excel, VBA, and Simul8. He has substantial experience of the health care system in the UK and other European countries.

Thaison has direct experience in building cost-effectiveness models from scratch and conducting big data analysis in several disease areas including dementia, vascular disease, and cancer.

Thaison’s PhD focus was to develop a de novo patient level model for the evaluation of different cognitive screening tests for early detection of dementia and mild cognitive impairment in primary care. He also looked at different methods for conducting economic evaluation in health care taking a broader/societal perspective. In addition, he investigated the use of Multiple Criteria Decision Analysis (MCDA) for economic evaluation.

Thaison also holds Academic Researcher position in School of Health and Related Research (ScHARR), University of Sheffield, UK and Honorary Researcher position in University of Bristol, UK.

Thaison’s likes to meditate, and play badminton, basketball and tennis.

Shilpi Swami

Specialty
Consulting and strategy

Role
Vice President

Degree
MSc. International Economics

Shilpi Swami

MSc. International Economics

Shilpi Swami is a seasoned Health Economics and Outcomes Research (HEOR) expert with experience spanning across multiple healthcare systems and therapy areas. At her current role of Vice President, HTA and Strategy, ConnectHEOR, she provides technical and strategic leadership. Additionally, Shilpi serves as the Member Engagement Co-Chair at ISPOR Oncology Special Interest Group.

Shilpi has a comprehensive track record of leading HTA submissions and devising market access strategies on a global scale, including the EU-5, Canada, US, Latin America, Australia, and Asia. Shilpi has worked across various sectors within health economics, including academia, consulting, and biopharma. This multidimensional experience equips her with a unique ability to offer strategic insights from various stakeholders’ perspectives.

Formerly a Research Fellow at the University of York, Shilpi has made significant contributions to public health projects and the development of best practices in the academic side of health economics. In her professional endeavors, she remains dedicated to improving healthcare through data-driven insights and evidence-based research

Hugo Pedder

Specialty Statistical Analysis and Evidence Synthesis

Role Senior Consultant

Degree PhD – Statistical Modelling

Hugo Pedder

PhD – Statistical Modelling

Hugo brings in a wealth of experience to ConnectHEOR from his extensive work in academia, focusing primarily on evidence synthesis and meta-analysis. Hugo holds PhD in Statistical Modelling from University of Briston and MSc in Medical Statistics from the London School of Hygiene and Tropical Medicine, and his background in neuroscience remains a passionate interest. Alongside working with ConnectHEOR, Hugo continues to part of NICE committee. His expertise includes advanced indirect treatment comparisons technique and has extensive experience of working with the NICE in UK. 

Beyond professional endeavors, Hugo is an enthusiastic outdoor adventurer, particularly enjoying mountain activities, climbing and ski mountaineering. From building rafts to exploring rivers in north of Sweden, he has lived an adventurous life outside of work and plans to continue to do so.

Kunal Hriday

Specialty
Data science and Strategy

Role
Senior Consultant

Degree
MSc. Quantitative Economics

Kunal Hriday

MSc. Quantitative Economics

Kunal Hriday is a business strategy and data science professional with experience in helping organizations crack through notorious business challenges. Kunal is proficient in business analytics, data analytics, product lifecycle management and business development. Working as a Data analytics consultant he has spent time in problem solving across variety of industries including Banking, logistics and Health and is now fully dedicated to HEOR. Kunal has hands on experience in various statistical programming tools and languages like R, Python, SAS, Excel VBA, Data Robot and data visualization tools like Power BI, Tableau and SAS VA.

Kunal also holds a Masters in Quantitative Economics from Indian Statistical Institute and a bachelors degree in Business Economics. Excellent in business communication, he is passionate about studying environmental economics and related theories of welfare optimization.

Raju Gautam

Specialty
Evidence Review

Role
Principal Consultant

Degree
PhD (Pharmacy)

Raju Gautam

PhD Pharmacy

Raju Gautam spearheads evidence review at ConnectHEOR and  has extensive work experience in evidence review and synthesis, value communications, scientific publications, medical writing and project management.
His expertise lies in systematic and targeted literature reviews, meta-analyses, network meta-analyses, value communications (AMCP and Global Value Dossiers), RWE study design and publications (manuscripts, posters, and abstracts).
He has experience working in Global pharma companies, consulting and CRO environment for several therapy areas including Cardiovascular, Oncology, Neurology, Respiratory, Ophthalmic, Rare Diseases, and Vaccines. He has more than 40 publications in international journals as an author.
Raju also likes jogging, yoga and meditation.

Radha Sharma

Specialty:
Patient preference research, survey, In-depth interviews, COA, Evidence review and conceptualisation of study

Role:
Director – Patient-Centered Outcomes Research

Degree:
MBBS (Bachelor of Medicine and Bachelor of Surgery), PhD (Global Public Health) – University of York

Radha Sharma

PhD (Global Public Health)

Radha Sharma spearheads Patient-Centered Outcomes Research at ConnectHEOR. She has a background in medicine, public health, and epidemiology.

Her expertise includes global health research, preference elicitation, mixed-method studies, consensus workshops, qualitative health research, epidemiological analysis of big data sets, RWE study design, scientific writing, and literature reviews. Her primary focus is integrating patient perspectives into all stages of health technology assessment (HTA) and healthcare decision-making processes.

Her extensive expertise in mixed-method studies and active patient/stakeholder engagement ensures that her research is methodologically rigorous and patient-centric. Radha is an avid hiker and enjoys exploring the beautiful Canadian Rockies.

Kate Ren

Specialty
Statistical Analysis and Evidence Synthesis

Role
Director of Statistics

Degree
Ph.D Probability and Statistics

Kate Ren

PhD Probability and Statistics

Kate spearheads Statistics and Evidence Synthesis at ConnectHEOR. She has more than 10 years of experience in conducting statistical analysis in HTA. Kate has PhD in Probability and Statistics specialising in Bayesian methods in clinical trial design.

She specializes in Bayesian methods in health economics and the elicitation of experts’ beliefs and has extensive experience of conducting evidence synthesis, including, meta-analysis, network meta-analysis, MAIC, STC, ML-NMR etc. Besides working with ConnectHEOR, she is also a part of NICE Committee and University of Sheffield.

Tushar Srivastava

Specialty
Decision Modelling and AI Initiatives

Role
Director and Principal Consultant

Degree
MSc – Statistics and Computing

Tushar Srivastava

MSc – Statistics and Computing

Endorsed as a ‘Global Talent’ by prestigious ‘The Royal Society, UK’, Tushar is dynamic and enjoys approaching complex problems with a holistic approach. He also holds an MSc. in Statistics and has authored a handbook on higher Mathematics, “A concise handbook of vector space theory and field theory, Srivastava T.”

In ConnectHEOR, Tushar spearhead all HEOR activities.

Tushar’s technical expertise lies in different techniques including cost-effectiveness modelling, budget impact modelling, simulation modelling, statistical modelling and indirect comparisons analysis. He brings a unique blend of academic research, technical modelling and statistical skills and industry professionalism to support the life science industry at every stage of the product life cycle. He has a good experience in statistical analyses, including survival analysis and health related quality of life data analysis from clinical trials.

Besides work, Tushar enjoys playing badminton, jogging, and meditating.